What is the appropriate dopamine infusion dose for an adult during ACLS?

The appropriate dopamine infusion dose during Advanced Cardiovascular Life Support (ACLS) for adult patients is typically recognized as being within the range of 2-10 mcg/kg/min. This dosage range is commonly utilized to achieve positive inotropic effects, which can improve cardiac output by enhancing the contractility of the heart muscle.

In acute settings such as cardiac arrest or severe hypotension, dopamine can be administered to support hemodynamics. At the infusion rate of 2-10 mcg/kg/min, dopamine primarily stimulates dopaminergic receptors, resulting in renal vasodilation and increased renal perfusion. This might also promote cardiac output without significantly increasing the heart rate at lower doses, allowing for a more stable cardiac performance.

Dopamine's effects can vary at different dosages; at higher infusion rates, it may also stimulate beta-adrenergic receptors leading to increased heart rate and cardiac output, along with alpha-adrenergic effects causing vasoconstriction. However, for an initial and appropriate use during ACLS, particularly focusing on supporting cardiac function and blood pressure, the 2-10 mcg/kg/min range is considered optimal, aligning with current guidelines and practices.