What is a primary indication for Fresh Frozen Plasma (FFP) transfusions?

Fresh Frozen Plasma (FFP) transfusions are primarily indicated in cases where there is a need to correct coagulopathy, particularly when patients have a significant deficiency of clotting factors. This condition is commonly seen in liver failure. The liver is responsible for producing most of the clotting factors in the blood; therefore, when it is not functioning properly—due to cirrhosis, acute liver failure, or other related conditions—there can be a substantial decrease in these vital proteins.

In liver failure, the risk of bleeding increases due to the lack of these clotting factors. Administering FFP can help restore the levels of these factors and improve coagulation, thereby reducing the risk of hemorrhage.

While FFP may be used in other scenarios such as during elective surgery, in cases of minor bleeding, or in post-operative recovery, these situations would typically not be primary indications for FFP. Instead, they could involve different treatment strategies or transfusions based on the specific needs of the patient and the clinical judgment of the healthcare provider.