What condition does a tricuspid valve vegetation commonly lead to in IV drug users?

Tricuspid valve vegetation in intravenous (IV) drug users is commonly associated with the development of pulmonary embolism. This condition arises because the introduction of pathogens into the bloodstream through contaminated needles can lead to infective endocarditis, particularly affecting the tricuspid valve. The resulting vegetations can break free and travel through the right side of the heart, entering the pulmonary circulation.

When a piece of the vegetation dislodges, it can travel to the pulmonary arteries, causing a blockage. This blockage can lead to symptoms associated with pulmonary embolism, such as chest pain, difficulty breathing, and increased heart rate. In IV drug users, where tricuspid valve infections are more prevalent, this progression to pulmonary embolism is a critical concern and a significant complication of their condition.