For severe asthma management, which additional treatment may be considered besides the interventions for moderate to severe asthma?

In the context of managing severe asthma, intubation becomes a vital consideration when a patient experiences refractory hypoxemia, meaning they are not responding to typical treatments and continue to have dangerously low oxygen levels. This situation may indicate that the patient's airway is too compromised due to severe bronchospasm or edema, which can lead to respiratory failure.

Intubation provides a way to secure the airway and ensure adequate ventilation and oxygenation, especially when non-invasive methods fail to stabilize the patient. In severe cases, the use of mechanical ventilation can help manage airflow and support the patient's breathing until the underlying asthma exacerbation can be resolved.

The other options, while potentially useful in varying circumstances of asthma management, do not specifically address the critical need for airway protection and ventilation support in a patient suffering from severe asthma and hypoxemia.