A STEMI results from what type of blockage?

A STEMI, or ST-Elevation Myocardial Infarction, occurs as a result of a complete occlusion of a coronary artery. This type of blockage typically arises when a thrombus (blood clot) forms on a ruptured atherosclerotic plaque, creating an obstruction that totally restricts blood flow to a portion of the heart muscle. When the blood supply is cut off entirely, the affected myocardial tissue begins to suffer from ischemia and, if not promptly treated, can lead to necrosis, resulting in significant heart damage.

Understanding the nature of the blockage in a STEMI is crucial because it informs treatment decisions. In cases of total blockage, immediate interventions such as percutaneous coronary intervention (PCI) or thrombolytics are often required to restore blood flow and minimize heart damage. This specific type of blockage distinguishes STEMI from other forms of acute coronary syndromes, such as NSTEMI (Non-ST-Elevation Myocardial Infarction), which may be due to partial occlusions or other mechanisms that do not result in full loss of blood supply.